The Curious Link Between Estrogen, Thyroid, Histamine, and Cortisol – Adrenal Series #6

Estrogen dominance, hypothyroidism, histamine intolerance, and high cortisol are all closely connected, and in fact they all stem from the same root cause. Fix it and the rest will fall into place. Start fixing the wrong one on its own and you’ll make the rest worse. It’s fascinating! It took me more than two years to connect all these dots and I’m super excited to put all of that knowledge into one concise video. I really hope this information will blow your mind as it did with mine.

To sum it up:

  • High estrogen (or estrogen dominance) creates more histamine.
  • High histamine promotes production of more estrogen, and the vicious cycle keeps feeding on itself.
  • Cortisol is your body’s antidote to histamine, so more cortisol is released to bring those histamine levels down.
  • High cortisol slows down thyroid function (as does high estrogen), which then leads to a sluggish liver and even more estrogen and histamine. And yes, you guessed it, more hypothyroidism.

Watch the video to learn more:

To be honest with you, I consider this video to be the most profound self healing video I’ve ever made because this information is life changing. Connecting these symptoms is the straightest road to resolving them. I can’t believe that none of the doctors are getting it.

If you know anyone who’s suffering with these health issues, please help them by sharing this information with them. It’s time to stop looking at separate symptoms without looking at the bigger picture.

This is Part 6 of the Adrenal Series, which means it’s the last one! I’m already super excited about the next one which is going to be all about estrogen dominance, low progesterone, period problems, and female hormonal balance in general. Let me know if there’s a particular topic you want me to address in that series. It’s going to be a huge one! There’s so much to talk about.

If you missed any of the previous posts about adrenal health, here they are:

Thank you for reading/watching!

Simply yours,
Vita xx

Disclaimer: My videos aren’t meant to give medical advice, treat, or diagnose. All I do is share everything I learn during my own healing and self-improvement journey. Please do your own research before trying anything and remember to always make well informed decisions because knowledge is power. 


  1. Hey Vita,

    I am a 27 year old male with high TPOabs, high Estrogen and Testosterone, low Ferritin and Histamine Intolerance. To conventional medicine, I am just normal. That’s why I have been trying to have an understanding and make nutrition my healer.

    Your connection makes sense to me, but what is the source of this knowledge? Do you somehow have any tips for men with Hashimoto’s?


    • It’s very unusual to see a guy with Hashimoto’s, but if you have high estrogen, it probably makes sense. Do you have any idea why your ferritin is low? Vegetarian or vegan diet perhaps? Ulcers? Overtraining perhaps? I made the connection after reading hundreds of books and articles. All the information is out there, just not many doctors or scientists are connecting everything yet. Everyone seems to only focus on their own field, not the whole body. xx

  2. Oh, I was expecting an e-mail notification. Just saw this.

    Well thanks! I guess I am special in a bad way. 🙂 I was following a Ketogenic Diet prior to my symptoms. Now checking on the nutrients of my diet, I was very malnourished. And a bit of overtraining I can say. So a low Ferritin is very well possible, but I also read of SIBO causing low Ferritin. Couldn’t have it tested though.

    I am currently increasing my intake of every micronutrient(especially Selenium and Zinc) with a big variety of veggies, whole grains(including gluten), seeds, some fruit, eggs, yogurt, canned sardines(!) and frozen mussels(!). Additionally I take a histamine reducing probiotic(Optibac). Things were going alright for a while, but I got a major flare up for the last 4 days, after some alcohol. I wonder if I do anything wrong. Should I do an Elimination Diet, instead of Nutrition?


    • Well, if you know that alcohol caused a flare up, just stay away from it. If a normal, real foods diet still causes troubles after a few weeks or months, then you can try an elimination diet, but don’t forget that recovering from a low carb can take a while. It took my digestion more than a year to recover after the Paleo diet. xx

  3. Hi Vita! I’ve just discovered your website and videos. I have all of the issues you mentioned and I thought that they were related but am sure of it now! I believe mine started with histamine issues…I have had stomach problems most of my life due to a history of eating disorders. This created an extremely leaky gut and I started getting histamine reactions after eating high histamine foods- but I had no idea and the sneezing and itching did not interfere too much with my life so I carried on… unfortunately it all came to a head when I started getting acid reflux that no amount of type of medicine could tame. My only option was to go he natural route and that’s when I discovered this whole world of holistic medicine. I have been following a low carb paleo low histaminw diet the last year and a half and now have prediabetes when taking in 50gm carbs per day. I have tingling sensations in my hands and feet also (You mentioned blood sugar issues in your 20 reasons why you stopped paleo). I also think it is due to increased cortisol which is related to insulin. I just hope I can get my health back!

    • Hi Jacqui, I became prediabetic as well due to the Paleo diet. It took several months for my blood sugar to stabilise after I went off it. I don’t have issues with it anymore. Eating low carb is very tricky for women (or anyone if you ask me). I would suggest checking your estradiol and progesterone levels because a hormonal imbalance would produce very similar symptoms as well. Also, the levels can change very quickly. For example, my estrogen was too high at the beginning of my healing journey. After doing regular fasts, exercising a lot, and taking estrogen metabolism supplements, it actually fell too low, now I’m working on bringing it back into balance. Cortisol is also very linked to hormones. Low thyroid function can also cause all of the symptoms, so if you haven’t had it done already, I would highly suggest checking your thyroid numbers. xx

  4. Hope Hollingsworth says

    I was a moody, irritable, allergic child so I think histamine metabolism could be genetically built in with me. As I am approaching menopause it is rearing its head worse than ever with migraines during ovulation and menses when I used to have none. My face is puffy (I feel sort of puffy and inflamed all over) and I have serious constipation. I have Hashimoto’s which has been treated for 20 years…until last year with synthroid/cytomel. I have actually become puffier since switching to Naturethroid nearly a year ago so I wonder about that link. But my #’s are always nicely in check.
    Two years ago a naturopath did blood work because I had a mysterious rash. She said it revealed markers for high systemic inflammation. Because she’s trained to see mold she concluded mold. Well, after treating my house it’s all the same.
    I have no idea what I should eat or what I should do. I have recently concluded that sugar triggers migraines. That’s all I’ve figured out. Should I cut gluten? I welcome any input at all. Such a rabbit hole…..

    • It’s truly a rabbit hole. Were you exposed to lots of stress as a child? Any childhood trauma? Or perhaps your mom was very stressed while carrying you? Any of these could weaken the adrenal glands, mess up the regulation of cortisol, which then would bring all the hormones out of whack. It does seem like you’re dealing with estrogen dominance. Ever checked your progesterone and estradiol levels? xx

  5. Michelle says

    Hi Vita!
    I just found your website and this post really resonates with my hashimoto’s journey. You’ve blown my mind on the histamine correlation. I never thought of it as a piece of the connected puzzle. After I had my first period around age 14 I began to have debilitating seasonal allergies – mainly sinus and eyes, as well as skin flare ups (and nosebleeds). I began taking birth control pills in my twenties, I can’t recall exactly when but my allergies began to subside, but it was probably within a two year period of me going on the pill. I always thought it was because I moved out of state (new environmental triggers). I was diagnosed with Adrenal Fatigue and Hashimoto’s when I was 26 after physical and emotional stress/trauma. That’s also when I got off the pill. Since then I’ve been working through finding the right nutrition and lifestyle for me, (stressful at times!). I’m now an avid fermenter, largely plant-based, but consider myself more of an intuitive eater, no dairy, very little gluten and refined sugar. Allergies have disappeared, except for the occasional sinus congestion. However, the Hashimoto’s and high antibodies still linger, and fatigue, currently treating with desiccated Thyroid. So I think I may have been Estrogen dominant from the start. Thanks for the interesting new perspective… I think I need to read more of your posts on this. Any additional thoughts on how to approach if from here are welcome.

    • Another interesting link I’ve found recently is vitamin B6. I’ll talk about it in my videos very soon. It’s just fascinating how one thing leads to another and how everything is connected. Slowly, slowly, all of the health issues can be unravelled. Wishing you lots of healing! <3

      • Interesting that you mention B6. I had a lifetime of miscarriages, infertility and allergies. My family has Thyroid history (Maternal Grandmother had Graves, My Mother, her twin sister and several other aunties all had Hashi’s. 3 female siblings and all of them have been diagnosed with Hashi’s (two older than me and one younger). I had blood tests just a couple of weeks ago and although my TSH FT3 and FT4 are all within normal I have TPOabs at 242 (my anti bodies were previously tested 9 years ago and were 19. I had been doing my research after a string of miscarriages when I was between the ages of 36 and 40. I read that there had been success with high doses of B6 (higher than recommended). I was nervous, but was aware of the signs of overdose and kind of figured I had nothing to lose. I took that and was taking Chaste Tree Berry tincture as well (for hormonal balance). I fell pregnant within the first month of starting, lost that one but fell pregnant again 2 months later (unheard of with my infertility). That one stuck and I gave birth at the age of 41 after 9 miscarriages. I am now 50 years old. During my pregnancy I felt the best I have EVER felt in my life. I have recently had my genes tested and I have several SNPs in the genes that relate to DAO enzyme which, as you know helps the body to clear histamine, but I also learnt that during pregnancy our bodies naturally produce a much higher ratio of DAO so that could explain why I felt energised and healthier than I ever have 🙂

        • Wow Mel, thank you so much for sharing your story! Your family history sounds so much like mine. I wonder if both of our families have genetic mutations making it difficult to convert B6 to P-5-P (have you seen one of my latest video about Morton’s Toe – it’s a fascinating topic!). I’m so happy that you finally had a successful pregnancy. It’s a true miracle, and another proof that supplements change and save lives. <3

  6. Vita – this video is amazing! Thanks for sharing. I began having pretty bad inflammation and dry eyes a few months after I went off birth control. It went downhill and I got hypothyroidism. I’ve done the food sensitivity diet, got rid of Candida, but eyes still inflamed and I cannot get my T3 in a good place – yet all other numbers look good. I blame this on the birth control! The good news is my cortisol is healthy. Estrogen blood tests came out normal, but my eyes are always worse around my cycle – especially right before it. I’m on a 3-week anti-histamine diet and it’s really hard. No relief. Still desperate to help my eyes! Any tips would be welcome!

    • Have you had your progesterone levels checked as well? Because progesterone is very low just before the period and during it. Progesterone is also a histamine neutraliser. So glad you found the video helpful! It’s truly fascinating how everything in our bodies is connected, yet the medical community still insists on looking at individual organs and symptoms only. <3

  7. Hi – very useful video. I am glad I found your site. It’s really hard to sum up what is happening with me without going into too much detail. Late 30’s my periods got heavy, developed a fibroid and got hashis. My sis had Graves so thought it ran in the family. Now I look back, I wonder if my probs started in the gut when I started taking artificial sweeteners. I drank more than 10 cups of instant coffee a day so if nothing else, that was a huge amount of artificial sweetener. Given synthetic T4 for thyroid probs. Felt worse in some ways. developed indigestion, high cholesterol, etc. Did my own research and found out natural dessicated thyroid (NDT) seemed to work better for some. I went on it for 5 years and felt pretty good. The only problem was that my sleep patterns became very erratic, so much so I had to work from home. I could sleep at the drop of a hat in the day but could NOT sleep at night. I’ve gone 36 hours without sleep in the past, more than once. Anyway, had a procedure to cut off blood supply to fibroid and that seemed sorted. Periods got lighter over the years and cycle got shorter until finally stopped a couple of years ago. At that time, I was living in a flat I didn’t realise until I got very ill, was moldy. So, breathlessness and dizziness on exertion lead me to hospital and a diagnosis of pulmonary hypertension. It came on suddenly (something my docs wont believe). then I got histamine intolerance! My own theory is that I was ignoring an underlying inflammation that was actually the root cause of my thyroid issue. ED due to age probably added to the mix, and then taking much too high doses of NDT (which I could tolerate because I was obviously in the cortisol/estrogen/thyroid/histamine cycle you discuss). Docs took me off NDT and put me on Levothyroxine, which seemed to alleviate all of my symptoms but did not reduce my arterial pressures. I realised recently that this was when my HIT symptoms really began to show up. I have found out since that synthetic T4 suppresses DAO (this clears histamine) while T3 can increase histamine levels. As can estrogen. As does cortisol. And ALL of these individually can lead to increased arterial pressures…as can mold (due to chronic inflammatory response syndrome). It’s taken me a LONG time to get to the point where my main problem is this persistent HIT. As I said though, I just found out Levo can suppress DAO so I am gonna go back on a much lower dose of NDT and see if it sorts out the HIT. A good probiotic might help too. Sharing my journey as it might prompt others to start looking at something that might not have occurred to them. Fascinating that this could all be from the same issue – my gut (in my case). My diet was lousy before I got ill. I ate like a teenager, lol. Too much sugar and Omega 6. Thanks again for sharing this info. It’s potentially life saving. By the way, since I started making the histamine/symptom connection last year, my arterial pressures are reducing, which is a relief because a few years ago, the prognosis for this disease wasn’t great. Things have improved a lot regarding treatment and the outlook isn’t as dire as it used to be but, as I said, I am heading in the right direction. Thanks again.

    • Thank you so much for sharing your story, and it’s incredible how everything is connected. Glad for you that you’re finally finding answers, and wishing you lots of healing! <3

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